Substantial differences between tumor and neighboring healthy cortex were found in both interstitial matrix proteins, such as collagen 6 (COL6A1, COL6A2, COL6A3), and basement membrane components such as collagen 4 (COL4A1, COL4A2) and laminins (LAMA5, LAMA4, LAMB1, LAMB2, LAMC1) (Figure 2C). This evidence concerns the gene COL4A1 and neoplasm.