NFKB1 and cancer: Surprisingly, AS1411 did not affect the phosphorylation of NFκB; these results disagree with those reported by Girva et al., showing that AGRO-100 aptamers (same sequence as AS1411) inhibited NFκB activity in tumor cells suggesting a role in regulation of IKK complex [66]; but, NFκB signaling is often deregulated in many cancer cells, which could explain our findings.