CTNNB1 and hemoglobin measurement: Other signs of an HB nature include the corresponding parameters of the Wnt/β-catenin signaling pathway and dysregulation of cell growth and survival pathways such as fetal and embryonal HB [44], a characteristic deletion of the third exon of the CTNNB1 gene, which is identical to that described in epithelial type HB, as well as similar gene expression profiles in HepG2 and tumor cells in hepatoblastoma [29].