In the case of HCC, the major pathways involved in the oncogenic process, in addition, to Wnt/b-catenin [54], are Hedgehog, hepatocyte growth factor/c-MET, vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK)/ERK (or Ras-Raf-MEK-ERK), and PI3K/AKT/Mtor [166]. Here, VEGFA is linked to hepatocellular carcinoma.