VHL and nonpapillary renal cell carcinoma: The key molecular features of ccRCC include inactivation of VHL tumor suppressor, which occurs in up to 90% of cases, as well as frequent mutations of the PI3K/Akt pathway, SETD2 (H3K36 methyltransferase), and genes encoding the elements of the SWI/SNF complex (PBMR1, ARID1A, and SMARCA4) [11,12].