DLG4 and Huntington disease: We confirmed that the reduction of PSD-95 protein levels is consistent at the transcript level by RT-qPCR analyses of Dlg4 mRNA levels in zQ175 mice compared to WT, in an immortalized striatal cell model of HD (STHdhQ111) compared to control (STHdhQ7) and in postmortem striatal samples from patients with HD (Supplementary Figure S1), as previously reported [6].