SV2A and neoplasm: Although their tumor uptake values (0.80 ± 0.23 %ID/g and 1.08 ± 0.16 %ID/g, respectively) were at a similar level to that of 18F-SynVesT-1 within 10–30 min p.i., a significant reduction was observed for both agents (p ≤ 0.01) within 40–60 min p.i. It indicated the retention of 18F-SynVesT-1 was SV2A-specific in the tumors, while the tumor accumulation of 68Ga-PSMA-11 and 68Ga-DOTATATE was not related to NED (Figure 5B).