Given that several SV2A specific radiotracers (e.g.,11C-UCB-A [46], 11C-UCB-J [47], 18F-UCB-H [48], and 18F-SDM-8/SynVesT-1/2 [49,50]) have been reported for synaptic density PET imaging of neurodegenerative diseases [51,52], we performed a PET imaging evaluation in an NEPC xenograft model using 18F-SynVesT-1, after having confirmed SV2A protein expression in NEPC cell lines and mouse xenografts through a comparative study. The gene discussed is SV2A; the disease is neurodegenerative disease.