For this purpose, we employed monocyte adhesion to human umbilical vein endothelial cells (HUVECs) and HFD-induced atherosclerosis development in ApoE knockout (KO) mice along with O-1602 as a GPR55 agonist [15,19] and CID16020046 as a specific GPR55 antagonist [20]. This evidence concerns the gene GPR55 and atherosclerosis.