In addition to the specific CA-4 resistance of HT29 cells, the cisplatin-resistant germ cell tumor cell line 1411HP generally showed a lower sensitivity to CA-4 and the imidazoles when compared with its cisplatin-sensitive counterpart cell line H12.1 but also when compared with the other cell lines (Figure 1a, Table 1). The gene discussed is CA4; the disease is testicular germ cell tumor.