Serum biomarkers of HCC such as alpha-fetoprotein (AFP), AFP-L3 (a glycoform of AFP), des-gamma-carboxyprothrombin, glypican-3 (GPC3), or osteopontin [13] may provide information about the biological aggressiveness of HCC but, unfortunately, they are not sufficiently accurate to form part of screening strategies. This evidence concerns the gene SPP1 and hepatocellular carcinoma.