The SDF-1/CXCR4 axis participates in the acquisition of stemness and migratory potential of HCC cells and could be considered a potential target to prevent metastases [136], with promising results obtained in preclinical studies targeting CXCR4 [137,138] or SDF-1 [139] by specific inhibitors or gene expressing traps respectively. This evidence concerns the gene CXCL12 and hepatocellular carcinoma.