MAPK1 and neoplasm: Indeed, several pro-proliferation proteins were uniquely identified in CM2D such as PICALM, which positively regulate cell proliferation [37] and GPC6, MAPK1, ILK and MIF, all involved in cell proliferation, migration and invasion, including that of tumor cells [38,39,40,41,42], cardiomyocytes and endothelial cells [38,39].