CCN3 and cardiac hypertrophy: Furthermore, upon proteomic analysis of CM3D, a variety of proteins stood out, including CCN3, a pro-angiogenic, anti-inflammatory and anti-fibrotic protein [56,57], COX6B1 that has been shown to reduce cell apoptosis and ROS levels in non-tumor cells by regulation of mitochondrial function [58], and S100A16, involved in cardiomyocyte apoptosis and cardiac hypertrophy reduction [59].