OLFML3 and glioblastoma: While low-grade gliomas (LGG, n = 592) had increased OLFML3 mRNA levels relative to normal brain ((Normal, n = 1141; p < 0.001), glioblastomas (GBM, n = 166) had increased OLFML3 mRNA expression relative to both LGG (p < 0.001) and normal brain (p < 0.001) (Figure 1A).