Studies on the role of S100A12 as a biomarker were similar to those on S100A8/A9 in SJIA and AOSD patients, with these levels being elevated in active SJIA or AOSD patients as compared to HC and associated with inflammatory markers, such as ESR, CRP, and ferritin, and the systemic score [106,107]. The gene discussed is ESR1; the disease is adult-onset Still disease.