Meanwhile, since more FGFR2 SNPs were reported in skeletal class III malocclusion than in skeletal class II malocclusion, the influence of the FGFR2→PLCγ2→NFATc1 cassette may be more common and notable for skeletal class III malocclusion progression; however, further investigation targeting a population of greater diversity should be conducted to test this hypothesis. Here, FGFR2 is linked to Dental malocclusion.