On the other hand, the ATCC12228EVs treatment decreased the mRNAs skin expression of VEGF-A, IL-6, KC, IL-17F, IL-23 (Figure 4B), and the IL-36 family members IL-36γ and IL-36R (Figure 4C), compared to the IMQ-induced psoriasis skin mice with no EV treatment. This evidence concerns the gene IL1RL2 and psoriasis.