Therefore, in this study, we aimed to investigate whether PCSK9 influences the expression of selected chemokine receptors as well as cytokines that are well known to participate in atherosclerosis and other cardiovascular complications (CXCR4, CCR8, CCR5, and CCR2) in in vitro and in vivo models, which could unveil a novel approach to modulate vascular inflammation. The gene discussed is CXCR4; the disease is atherosclerosis.