For instance, circulating PCSK9 has effects on platelet reactivity [14], Apolipoprotein E receptor 2 (ApoER2) [15], and Cluster of differentiation 36 (CD36) [16] independent of LDLR in causing vascular aging, hypertension, myocardial infarction, and atherosclerosis. Here, LRP8 is linked to hypertensive disorder.