EGFR and cancer: Compared with female fish, the up-regulated genes in male fish were mostly related to disease-related regulatory pathways, such as Proteoglycans in cancer (pathway ID: ko05205), Type II diabetes mellitus, Renal cell carcinoma, etc. The expression of genes involved in EGFR tyrosine kinase inhibitors (pathway ID: ko01521) and the ErbB signaling pathway (pathway ID: ko04012) was also up-regulated.