While FL and CLL/MBL had a similar pattern overall, FL showed a more frequent contribution of mutation in contexts associated with the canonical (c-AID) and non-canonical (nc-AID) AID motifs than CLL/MBL (Figure 3B, FL: 33.43% and CLL: 24.77%). The gene discussed is AICDA; the disease is B-cell chronic lymphocytic leukemia.