NLRP3 and Alzheimer disease: Several studies have reported that the NLRP3-inflammasome is activated in microglia, increasing the expressions of inflammasome-forming factors, such as NLRP3, caspase-1, and ASC, leading to increased secretion of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18, inducing neuronal death in patients with AD [95,96,97].