TLR4 and rheumatoid arthritis: TAK 242 (resatorvid) is a specific TLR4 inhibitor that has potent anti-inflammatory activity in a variety of inflammatory diseases [20,21,22,23,24,25], including endotoxemia-induced skeletal muscle wasting [37], sepsis [20,22,24,38], acute kidney injury [39], neuroinflammation [40], acute cerebral ischemia [41], cancer [42], and rheumatoid arthritis [43].