TGFB1 and central nervous system cancer: However, although EMT may be a common pattern in glioma progression, the therapeutic interventions affecting the occurrence and magnitude of EMT during the clinical course of GBM still remains a constant challenge [43,44], as the microenvironment that induces EMT in gliomas is characterized by hypoxia and the enrichment of myeloid cells following stimulation by TGF-β [45].