Among specific brain cancer biomarkers promoting invasion and metastasis and characterized by both matrix metalloproteinase (MMP) catalytic functions and intracellular signaling properties, membrane type-1 matrix metalloproteinase (MT1-MMP), a key membrane-bound MMP, is involved in extracellular matrix (ECM) degradation [19,20,21] and, more recently, signal transducing functions leading to angiogenesis [22], autophagy [23,24], inflammation [25,26], immune response [27], and cell death processes [28,29]. This evidence concerns the gene MMP14 and brain cancer.