In addition, hyperglycemia in the blood of rats of the first group could be explained by the development of gluconeogenesis, since overexposure to ethanol is known to lead to insulin resistance in the liver, which increases the enzymatic capacity of gluconeogenesis and lipogenesis and decreases glycogen synthesis by inhibiting the PI3K/AKT signaling pathway in the liver [70]. This evidence concerns the gene AKT1 and Insulin resistance.