In a comparative study between [18F]THK5117 (Tau) and [11C]PiB (Aβ) PET, Li et al. observed that on average Tau tracer positive-voxels were closer to the white matter than the Aβ tracer positive voxels in all AD subjects and for all regions, both before and after regionally adjusting for the non-specific white-matter binding of both tracers. This evidence concerns the gene MAPT and Alzheimer disease.