In addition, [11C]PBB3 deposition in the frontoparietal white matter was correlated with the general severity of Parkinsonian and PSP symptoms, whereas both gray matter and white matter tracer accumulations in the frontoparietal cortices were associated with nonverbal cognitive impairments [118], supporting the promising role of Tau PET imaging in tauopathy assessment. This evidence concerns the gene MAPT and tauopathy.