RYR2 and Duchenne muscular dystrophy: As suggested by the promising results of combining RYR stabilizers and exon skipping therapies in DMD iDRMs, iPSC-derived myotubes [56,57] and patient iPSCs-derived cardiomyocytes [64] and in muscle function in mdx mice [38,62], our study highlights the potential effect of RYR1 stabilization as an adjunctive therapeutic strategy in patients with DMD.