Additionally, hypermethylation of 21 out of 39 T2D candidate genes was observed, of which 4, Hematopoietically Expressed Homeobox (HHEX), Insulin Like Growth Factor 2 MRNA Binding Protein 2 (IGF2BP2), JAZF Zinc Finger 1 (JAZF1), and TCF7L2, had reduced expression. The gene discussed is HHEX; the disease is type 2 diabetes mellitus.