Six-month endurance exercises with one session of one-hour spinning and two sessions of one-hour aerobic per week depicted methylation differences in 21 of 39 T2D candidate genes, of which Thyroid Adenoma Associated (THADA) and RNA Binding Motif Single Stranded Interacting Protein 1 (RBMS1) showed significant differences and 18 of them being nominal differences between groups with family history [34,45]. This evidence concerns the gene RBMS1 and type 2 diabetes mellitus.