Hypermethylation was observed in adipocytes with a simultaneous decrease in expression in the genes GABA receptors (GABBR1), modifying histones Euchromatic Histone Lysine Methyltransferase 1 (EHMT1), Euchromatic Histone Lysine Methyltransferase 2 (EHMT2) and Histone Deacetylase 4 (HDAC4), transcriptional co-repressor the Nuclear Receptor Corepressor 2 (NCOR2), and the pathogenesis-related metabolic syndrome and trafficking GLUT4 RalA Binding Protein 1 (RALBP1). Here, HDAC4 is linked to metabolic syndrome.