In addition, hypermethylation of 18 obesity candidate genes was observed, of which two of the Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4) and Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) had reduced expression. The gene discussed is CPEB4; the disease is obesity due to melanocortin 4 receptor deficiency.