Another hallmark of AD pathology, the formation of intracellular neurofibrillary tangles or NFTS, results from the hyper phosphorylation and aggregation of the tau protein thought to be modulated by the activated GABA receptor, which induces phosphorylation at the AT8 epitope (Ser-199/Ser-202/Thr-205) in cultured mature cortical neurons. This evidence concerns the gene MAPT and Alzheimer disease.