For example, FANCL has many variants, such as the known substrate binding mutants (W212A, W214A and L248A, F252A, L254A, I265A), an FA mutation (R221C), and 14 cancer-associated mutations (F110S, I136V, L149V, L154S, A192G, E215Q, E217K, R221W, T224K, M247V, F252L, N270K, V287G, and E289Q) [89]. This evidence concerns the gene FANCA and cancer.