GCLM and liver cancer: In a study on fatty acids in Coriandrum sativum L., Abiko et al. reported that covalent modification by the 2-alkenyl group of aliphatic electrophiles activated Nrf2/Keap1 and increased the expression of Gclm and HO-1, which are downstream of Nrf2 in HepG2, in a liver cancer cell line.