NOS2 and cancer: nEGFR, as a molecular target in cancer, functions as a cotranscription factor for the expression of several oncogenes: cyclin D1, inducible nitric oxide synthase (iNOS), B-Myb, Aurora kinase A, cyclooxygenase 2 (COX2), c-Myc, breast cancer resistance protein (BCRP), and signal transducer and activator of transcription 1 (Stat1) [15,16,17,18,19,20,21].