More specifically, in recent years CD4+ T helper type 17 (Th17) cells that release IL-17, a crucial proinflammatory cytokine responsible for NAS progression [86], emerged as the primary lymphocyte subtype responsible for liver inflammation, and the ratio between Th17 and Treg as the major determinant for the progression of NASH [87]. Here, CD4 is linked to metabolic dysfunction-associated steatohepatitis.