The adoptive transfer of CD4 + CD45RBhigh T-cells (naive T-cells, depleted of the Treg cell population) from healthy wild-type (WT) mice into recipients that lack T- and B-cells induces pancolitis and small bowel inflammation following T-cell transfer, which thus successfully recapitulates the intestinal inflammation observed in human UC and CD [60]. Here, CD4 is linked to pancolitis.