Thus, the removal of the pro-inflammatory role of sympathetic nerves by 6-OHDA, and the administration and inhibition of the release of transmitters from enteric nerves by lidocaine in the presence of primary afferents, resulted in the greatest reduction of colitis manifestation (evidenced by macroscopic and microscopic scoring and myeloperoxidase activity) [50]. The gene discussed is MPO; the disease is colitis.