As depicted in the tSNE plots and summary analyses (Figure 2A–C), the frequency of TIGIT+, PVRIG+, CD39+, and CD69+ NK cells was significantly increased in the BM from patients with AML in comparison to PB mononuclear cells derived from HDs (p = 0.0002, p = 0.0024, p < 0.0001, p = 0.0022). The gene discussed is PVRIG; the disease is acute myeloid leukemia.