In this study, we focused on the (co-)expression of the inhibitory receptors TIGIT, PVRIG, PD-1, and LAG-3 as well as the ectonucleotidases CD39, CD73, and CD38 and we investigated whether TIGIT blockade together with blockade of the purinergic signaling can reinvigorate NK cell-mediated killing of AML blasts. This evidence concerns the gene CD38 and acute myeloid leukemia.