The single blockade of the TIGIT receptor resulted in an increased NK cell-mediated killing of AML cells after 24 h in all 3 AML cell lines (anti-TIGIT vs. IgG2a for MV-4-11 p = 0.001, for TF-1 p = 0.0078 and for OCI-AML3 p = 0.0156; Figure 5A). Here, TIGIT is linked to acute myeloid leukemia.