LEP and Insulin resistance: Therefore, to clarify the mechanism by which IH induces inflammation in adipose tissue and exacerbates insulin resistance, we examined the effects of IH exposure on TNF-α, IL-6, etc. A total of seven molecules were measured: six adipokines (ADIPOQ, RETN, LEP, CCL2, TNF-α, and IL-6), which are molecules involved in insulin resistance or whose expression is expected to be altered under IH conditions, and uncoupling protein-1 (UCP-1), which is secreted by brown adipocytes and promotes heat production.