NFKB1 and isolated hemihyperplasia: Since HIF-1 is a direct target, such as being transcriptionally regulated by NF-κB, and TNF-α is also regulated by NF-κB, it is possible that crosstalk between HIF-1 and NF-κB is associated with cytokine abnormalities under IH, but the detailed mechanism is not known [77,78].