BCL2 and Hermansky-Pudlak syndrome: Based on previous work and data presented here, we conclude that the improvement of liver injury by HPS is mainly relevant from four perspectives: Firstly, by stimulating hepatocyte regeneration through activation of MAPK/ERK pathway [4]; secondly, by attenuating hepatocytes apoptosis through decreased proapoptotic protein Bax and elevated antiapoptotic protein Bcl-2 [5,15]; thirdly, by reducing oxidative stress response; fourthly, by inhibiting inflammation.