Several TFs govern the gene expression programmes of neuroblastoma, notably including different CRC transcription factors, such as PHOX2B, HAND2, GATA3, ASCL1, ISL1, and TBX2, which show a clustered binding across open chromatin regions of their regulatory sequences, as well as those of the other CRC partners and those of many other driver master regulators, including MYCN and ALK. The gene discussed is ISL1; the disease is colorectal carcinoma.