EZH2 and neuroblastoma: Providing some examples, Gajer et al. [61] showed that inhibition of HAT activity in vitro and in vivo blocked NB cells growth; Chen et al. [54] demonstrated that knockdown of the PRC2 component EZH2 or its depletion upon inhibitor treatment resulted in markedly decreased NB cell viability; Yang et al. [62] proved that the silencing of the histone demethylase LSD1, a component of CoREST complexes, resulted in a reduction in cell proliferation, colony formation, migration, and invasion of NB cell lines.