A retrospective NGS-based analysis on 15 ROS-1 positive lung cancers, 1 case of concurrent MET mutation (R988C), 2 cases with BRAF mutations and 7 cases harboring TP53 mutations were reported: Taken together, all these alterations account for 66.7% of concomitant ROS1 and other genetic aberrations [99]. This evidence concerns the gene ROS1 and lung cancer.