Overexpression of SHP-1 in gastric cancer cells downregulated the JAK-STAT pathway (decreased phosphorylation of JAK2 and STAT3 due to its dephosphorylation activity) and led to the downregulation of proteins that are important for cell cycle progression, invasion, and angiogenesis (Cyclin D1, MMP-9, VEGF1) (Figure 1) [38]. This evidence concerns the gene CCND1 and gastric cancer.