KMT2D and exocrine pancreatic carcinoma: In addition, significant upregulation of a number of HMTs such as KMT5B, KMT2D (MLL2), NSD3 (nuclear SET domain-containing protein 3), PRDM16, MECOM (MDS1 and EVI1 complex locus protein) and NSD1 was observed in MCF7, MDA-MB-231, and pancreatic carcinoma PANC1 cell lines.