Yet, the authors showed that the ANCR-EZH2 interaction promotes the EZH2 binding to the promoter of suppressor of cytokine signalling 3 (SOCS3), increasing the level of H3K27me3 and inhibiting SOCS3 expression, which is associated with enhanced BC cell migration and invasion in vitro and in vivo [105]. The gene discussed is SOCS3; the disease is breast cancer.