Through comprehensive targeted inactivation, rescue and overexpression approaches in multiple in vivo models, the authors proved that MALAT1 plays the antimetastatic role by inhibiting the TEAD (TEA domain family member) TFs, which together with their coactivators YAP (Yes-associated protein 1) and TAZ (TEAD 4) promote tumour progression and metastasis through the transcriptional activity [103]. Here, YAP1 is linked to neoplasm.