PRDM14 and cancer: The enrichment of H3K27me3 might serve as a mark of the genes that need to be regulated by other proteins acting as histone methylation readers/erasers in cancer cells, for example, promoters containing both H3K4me3 and H3K27me3 histone marks coincided with strong binding sites of PRDM14, a zinc finger protein containing the PR domain homologous to the SET domain of KMTs [61].