Another lncRNA, a metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) that can silence gene expression through binding to the PRC2 complex followed by methylation of H3K27 in bladder cancer [100] was shown to be positively correlated with BC progression and metastasis in vitro and in vivo in the MMTV-PyMT mouse mammary tumor model of human luminal B BC [101]. This evidence concerns the gene MALAT1 and breast cancer.