Furthermore, in various studies carried out using preclinical animal models of MS; transgenic mice with multiple copies of cDNA that encodes PAD2 [22] and mice with MOG-induced-experimental autoimmune encephalomyelitis (EAE) [23], it was shown that the rapid progression of MS is mainly due to PAD-mediated citrullination of myelin basic protein, which is the main component of myelin sheath [2,24,25]. This evidence concerns the gene PADI2 and myeloid sarcoma.