GNAS and pancreatic intraductal papillary-mucinous neoplasm: McCarty R. T. et al. performed a metanalysis of six studies involving 785 pancreatic lesions and documented that the combination of KRAS and GNAS in the molecular analysis of cystic fluid had a sensitivity, specificity, and diagnostic accuracy of 94%, 91%, and 97% in the diagnosis of IPMN and mucinous cysts [75].