SQSTM1 and Niemann-Pick disease type C: Alexidine dihydrochloride was shown to have the most potent lysosomal cholesterol-reducing activity in a high-content screening for modifiers of Niemann-Pick type C disease [47] and it was also a hit of the previous cell-based phenotypic drug screening for compounds that reduced the autophagy-related protein p62/SQSTM1 levels in cystinotic cells [42].