Table 1 summarizes the potential functions of EREG. EREG is usually overexpressed in various human cancers such as bladder cancer [51,52,53], brain cancer [54,55,56,57], breast cancer [38,39,58,59,60,61,62,63], ovarian and cervical cancer [36,64], colorectal cancer [47,65,66,67,68,69,70,71,72], head and neck cancer [11,37,73,74,75,76], liver cancer [77,78], lung cancer [31,79,80,81,82], pancreatic cancer [83], prostate cancer [84], gastric cancer (GC) [85,86], and thymic cancer [35]. This evidence concerns the gene EREG and Familial prostate cancer.