This might be explained by possible engagement of the p110δ isoform in insulin signalling in hepatoma cells, as an earlier study had demonstrated that inhibition of the p110δ isoform in addition to p110α was required for substantial inhibition of insulin-stimulated Akt phosphorylation in HepG2 hepatoma cells [19]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.