ACE inhibitors are clinically acknowledged to possess such effects, however, ACE2 overexpression seems to have at least comparable cardioprotective effects similar to AT1R antagonists (irbesartan) [37] or it can be even more beneficial compared to ACE inhibitors (cilazapril) in the treatment of doxorubicin-induced cardiomyopathy [161]. This evidence concerns the gene ACE2 and cardiomyopathy.