In 2016, Moirangthem et al. showed that knockdown of MMP-9 in the breast cancer cell line MDA-MB-231 may reduce progression by increasing cell-to-cell adhesion and regulating EMT markers, including urokinase receptor (uPAR), E-cadherin, vimentin, and Snail. The gene discussed is MMP9; the disease is breast carcinoma.