Changes in the expression and/or subcellular localization of TIA1 have been associated with important pathophysiological consequences in human biology and disease, including embryogenesis [14,21,22], inflammation [14,23,24], tumorigenesis [25,26,27], neuronal homeostasis [28,29], tauopathies [30], myopathies [31,32,33,34,35], cell stress [10,11,12] and viral infections [2,36]. The gene discussed is TIA1; the disease is tauopathy.