Dudeffant et al. demonstrated the detection of compact Aβ plaques as well as CAA and microhemorrhages in five mouse lines (APPSL/PS1M146L, APP/PS1dE9, APP23, APPSwDI, and 3 × Tg) and in AD human brains using DOTAREM® (Gd-DOTA) at 7 T MRI even around a diameter of 25 μm [45]. The gene discussed is APP; the disease is Alzheimer disease.