In vivo MRI using T1 and T2 scans and histological evaluation has identified differences in the entire brain or regional brain volumes between amyloidosis animal models and wild-type littermates, including APP T714I, APP/PS1, APP/PS1 KI, 3 × Tg, and TASTPM mice and McGill-R-Thy1-APP rats [117,154,171,172,173,174,179,180,211] (Table 3). Here, APP is linked to amyloidosis.