Impairment in white matter integrity has been detected by using in vivo and ex vivo DTI MRI in APPswe, APP/PS1, TgCRND8, APPNL-G-F, 3 × Tg, CVN-AD, and 5 × FAD mice compared to wild-type mice [81,91,95,184,185,186,189,191,196,216,217,218] (Table 3). The gene discussed is APP; the disease is Alzheimer disease.