Moreover, the inhibition of mitophagy with 3-MA suppressed contrast exposure-induced apoptosis and NLRP3 inflammasome activation, and the inhibition of NLRP3 inflammasome with MCC950 suppressed contrast exposure-induced apoptosis, indicating that PINK1–Parkin-mediated mitophagy improved CI-AKI by inhibiting contrast exposure-induced apoptosis by suppressing NLRP3 inflammasome activation [52]. This evidence concerns the gene PRKN and acute kidney injury.