Additionally, given the role of cGAS–STING in regulating the expression of ISG15 at baseline and in response to DNA damage, this may be another mechanism by which the cGAS–STING signaling pathway regulates tumor intrinsic responses to genotoxic stress and is consistent with prior results showing decreased sensitivity to DNA-damaging therapies with STING loss, given the also demonstrated downregulation of ISG15 in this context. The gene discussed is ISG15; the disease is neoplasm.