One of the most relevant hypotheses describing OS as the main factor in AD pathophysiology is because neuronal cells have a higher intake of oxygen, elevated lipid content, and a lower content of antioxidant enzymes such as Cu/Zn-superoxide dismutase (SOD), glutathione (GSH) and catalase compared to other types of cells, making them more vulnerable to changes in OS [10,11,12,13]. Here, SOD1 is linked to Alzheimer disease.