Univariate and multivariate Cox regression analyses of the real-time RT-qPCR cohort indicated that BUB1 expression may be an independent predictor of progression in NMIBC patients [hazard ratio (HR), 4.642; 95% confidence interval (CI), 1.021–21.097; p = 0.047], and the HR was similar to that for tumor grade (HR, 4.629; 95% CI, 1.593–13.450; p = 0.005; Table 1). The gene discussed is BUB1; the disease is neoplasm.